How we ranked them: repeatable command-zone value, deck-building support, resilience, mana cost, and ability to convert setup into a win. This is a Commander evaluation, not a tournament-usage ranking.
Best overall - Set-wide engine
Prismari, the Inspiration
Give every instant and sorcery spell storm and make one spell-heavy turn multiply itself.
What the card does: Flying Ward—Pay 5 life. Instant and sorcery spells you cast have storm.
Among the new Secrets of Strixhaven legends, Prismari, the Inspiration ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 2
Moseo, Vein's New Dean
Turn life gain into scaled reanimation at every end step.
What the card does: Flying When Moseo enters, create a 1/1 black and green Pest creature token with "Whenever this token attacks, you gain 1 life." Infusion — At the beginning of your end step, if you gained life this turn, return up to one target creature card with mana value X or less from your graveyard to the battlefield, where X is the amount of life you gained this turn.
Among the new Secrets of Strixhaven legends, Moseo, Vein's New Dean ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 3
Witherbloom, the Balancer
Use a creature-heavy board to discount both the commander and your instant-and-sorcery game.
What the card does: Affinity for creatures Flying, deathtouch Instant and sorcery spells you cast have affinity for creatures.
Among the new Secrets of Strixhaven legends, Witherbloom, the Balancer ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 4
Dina, Essence Brewer
Draw from sacrifice once each turn, then convert a creature into life and permanent power.
What the card does: Whenever you sacrifice a creature, draw a card. This ability triggers only once each turn. {2}, {T}, Sacrifice another creature: You gain X life and put X +1/+1 counters on target creature you control, where X is the sacrificed creature's power.
Among the new Secrets of Strixhaven legends, Dina, Essence Brewer ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 5
Lorehold, the Historian
Give every instant and sorcery in hand miracle for two mana while looting on opposing upkeeps.
What the card does: Flying, haste Each instant and sorcery card in your hand has miracle {2}. At the beginning of each opponent's upkeep, you may discard a card. If you do, draw a card.
Among the new Secrets of Strixhaven legends, Lorehold, the Historian ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 6
Killian, Decisive Mentor
Auras tap and goad opposing creatures, then turn enchanted attackers into cards.
What the card does: Whenever an enchantment you control enters, tap up to one target creature and goad it. Whenever one or more creatures that are enchanted by an Aura you control attack, draw a card.
Among the new Secrets of Strixhaven legends, Killian, Decisive Mentor ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 7
Silverquill, the Disputant
Give every instant and sorcery casualty 1 so small creatures become copied spells.
What the card does: Flying, vigilance Each instant and sorcery spell you cast has casualty 1.
Among the new Secrets of Strixhaven legends, Silverquill, the Disputant ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 8
Blech, Loafing Pest
Every life-gain event grows an entire Pest, Bat, Insect, Snake, and Spider board.
What the card does: Whenever you gain life, put a +1/+1 counter on each Pest, Bat, Insect, Snake, and Spider you control.
Among the new Secrets of Strixhaven legends, Blech, Loafing Pest ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 9
Gorma, the Gullet
Creature deaths grow Gorma and make the next nontoken creature enter much larger.
What the card does: Lifelink Whenever another creature you control dies, put a +1/+1 counter on Gorma. Nontoken creatures you control enter with an additional +1/+1 counter on them for each creature that died under your control this turn.
Among the new Secrets of Strixhaven legends, Gorma, the Gullet ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.
Commander pick 10
Quandrix, the Proof
Cascade on the commander is only the start; spells cast from hand gain cascade too.
What the card does: Flying, trample Cascade Instant and sorcery spells you cast from your hand have cascade.
Among the new Secrets of Strixhaven legends, Quandrix, the Proof ranks here because its engine is repeatable, identifiable from the command zone, and supported by a coherent deck shell.